CD44 is a cell-surface glycoprotein that attaches to the extracellular matrix proteins hyaluronan, osteopontin, and selectin E. One study revealed that in comparison to normal HSCs, the expression of CD44 variant exons is more prevalent in AML cells [103] also some studies showed that high levels of CD44 molecules were essential for AML relapse in mouse models of AML [104]. Here, SPP1 is linked to acute myeloid leukemia.