APOE and Alzheimer disease: Moreover, several genetic variants have been associated with neuropathological events in late onset AD (LOAD), like APOE (Rebeck et al., 1993) including variants related to pathological processing of Tau and Aβ, neuroinflammation, oxidative stress, and the occurrence of neuronal, synaptic and mitochondrial dysfunction (Andrade-Guerrero et al., 2023; Nasb et al., 2024).