Other works have also explored regulation and co-expression networks to evaluate cerebrovascular effects of APOE genotypes (Panitch et al., 2022), and identification of master transcription factors in AD, where possible key factors in Alzheimer's disease have been discovered, such as the JMJD6 gene, which was also validated in an animal model (Merchant et al., 2023). The gene discussed is JMJD6; the disease is Alzheimer disease.