The role of angiogenesis-related genes as part of the pathophysiology of AD was also observed in a study by Seto et al. (2023), who used transcriptomic technologies to characterize brain changes in the vascular endothelial growth factor family during aging and AD, found that VEGFB and FLT1 expression were associated with worse outcomes, and that microglia, oligodendrocytes and endothelial may play a central role in these associations. Here, FLT1 is linked to Alzheimer disease.