Although further comparative studies between HSV- and VZV-infections in NSPHs are required, the induced formation of G3BP1+ SGs as such is a novel finding for VZV and has not previously been observed for wild-type HSV (81), although this may be cell-type and/or context dependent, and more specifically in our study the chosen (late) timing of analysis following initial infection. Here, G3BP1 is linked to infection.