Our observation that no Type-1 IFNs were detected in the culture supernatant in VZVeGFP-ORF23 and SeVeGFP infected NSPHs at day 3, day 5 or day 7 post-infection, is in fact also in line with our multiplex human immunology NanoString gene expression analysis, whereby no significant upregulation of IFN-α2 and IFN-β mRNA was noted (Supplementary Table 1). This evidence concerns the gene IFNB1 and infection.