Notably, the activity of immunosuppressive molecules like LAG3, LGALS9, PD-L1(PDCD1), and CTLA4 was negatively correlated with SCD expression, whereas immune-activating molecules such as TNFRSF18, TNFSF4, and CD47 were positively correlated. Here, TNFSF4 is linked to Schnyder corneal dystrophy.