To functionally assess the involvement of FcRn in basal-to-apical transcytosis in WD-HAE cultures, we next performed a competitive inhibition experiment using 10-fold excess of a clinical preparation of human IgG (4 mg of intravenous immunoglobulin (IVIG)) to the high dose of CR3022 (400 μg). This evidence concerns the gene FCGRT and Wilson disease.