Since MMP-9 overexpression facilitates the spread of cancer, understanding the intricate interplay between MMP-9 and other coplayers in breast cancer metastasis, such as TNF-α and TGF-β, is imperative to developing targeted therapeutic strategies to intercept the pro-metastatic pathways and alleviate breast cancer metastasis. Here, TGFB1 is linked to breast carcinoma.