CD33 on CD66b++ myeloid cell mediated the causal relationship between DHEAS (Mediated proportion = -7.86%[-15.1%,-0.631%]), Androstenediol (3beta,17beta) monosulfate (Mediated proportion = -11.8%[-21.3%, -2.25%]), Aspartate to N-acetylglucosamine to N-acetylgalactosamine ratio (Mediated proportion = -12%[-22.5%,-1.55%]), and lymphoid leukaemia. The gene discussed is CD33; the disease is lymphoid leukemia.