CD33 on CD33dim HLA DR+ CD11b+ mediated the causal relationship between DHEAS (Mediated proportion = -8.22%[-16.4%,-0.035%]), Androstenediol (3beta,17beta) monosulfate (Mediated proportion = -11%[-21.9%,-0.219%]), Aspartate to N-acetylglucosamine to N-acetylgalactosamine ratio (Mediated proportion = -13.5%[-25.4%,-1.68%]), and lymphoid leukaemia. The gene discussed is CD33; the disease is lymphoid leukemia.