Higher CD3 on Effector Memory CD8+ T cells was associated with an increased risk of ALL (OR[95% CI]=1.714[1.008-2.915], P=4.7e−02), and higher CD80 on granulocytes was associated with a decreased risk of ALL (OR [95%CI]=0.446 [0.211-0.943], P=3.5e−02). This evidence concerns the gene CD8A and acute lymphoblastic leukemia.