CD33 on CD14+ monocyte mediated the causal relationship between DHEAS (Mediated proportion = -9.72%[-17.8%,-1.65%]), Androstenediol (3beta,17beta) disulfate (Mediated proportion = -14.6% [-26.9%,-2.27%]), and lymphoid leukaemia. This evidence concerns the gene CD14 and lymphoid leukemia.