When the activated antigen-specific CD8+ T cells were adoptively co-transferred with either INS-eTregs together with INS-CD8+ T cells (1:1) or IGRP-eTregs together with IGRP- CD8+ T cells (1:1) diabetes development was significantly reduced, compared with 100% diabetes occurring in the absence of the eTregs (Figure 8B) (p<0.001). This evidence concerns the gene CD8A and diabetes mellitus.