This leads to increased release of neuropeptides such as pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), VEGF, adrenomedullin, calcitonin gene-related peptide (CGRP), and substance P (SP), all implicated in rosacea pathogenesis (125–127). The gene discussed is VEGFA; the disease is rosacea.