Furthermore, ANA-12 has been used to target NTRK2 in studies of medulloblastoma (Thomaz et al., 2019), gliomas (Pinheiro et al., 2017), leukemia (Polakowski et al., 2014), lung adenocarcinoma metastasis (Sinkevicius et al., 2014), lymphoid tissue neovascularization (Dalton et al., 2015) and endometriosis (Lee et al., 2021), etc. Experimental validation was performed on the hub gene. The gene discussed is NTRK2; the disease is central nervous system cancer.