Apoptosis is induced mainly by regulating key apoptotic proteins caspase-3 and Bcl-2; in addition, circ-SHPRH peptide-RUNX 1 interaction enhances expression of NFKBIA in neuroblastoma, which plays an important part in inhibiting the malignant progression of neuroblastoma. The gene discussed is SHPRH; the disease is neuroblastoma.