In summary, our results indicate that FFYH can effectively inhibit the replication of SARS-CoV-2 by blocking autophagy via the PI3K/AKT/mTOR signaling pathway and has a significant therapeutic effect by improving clinical symptoms, restoring hematological parameters, preventing disease progression, shortening the duration of hospitalization, and controlling excessive cytokine storms in mild COVID-19 patients, suggesting that FFYH may be a promising option for treating COVID-19. This evidence concerns the gene AKT1 and COVID-19.