Besides utilizing CAR activation pathways, NK cells can also exert their cytotoxic effects through their natural membrane receptors (natural cytotoxicity receptors, NCRs, such as NKG2D, NKp46, NKp30, NKp44), thereby reducing the risk of tumor immune evasion and relapse caused by the loss of tumor antigen expression. The gene discussed is NCR2; the disease is neoplasm.