Previous researches have identified various factors that can predict poor outcomes in bacterial meningitis, including reduced level of consciousness at admission, cranial nerve palsy, low white cell count in cerebrospinal fluid, and specific elements linked to pneumococcal infection (venerable age; otitis or sinusitis, pneumonia, or immunocom promise) or systemic compromise(cardiac acceleration and Increased C-reactive protein) (2, 9, 15, 16). The gene discussed is CRP; the disease is sinusitis.