IRS1 and acute myocardial infarction: In addition, another study reported that exosomal circ-HIPK3 reduced H2O2-induced apoptosis of AC16 cardiomyocytes and promoted proliferation via the miR-33a-5p/insulin receptor substrate 1 (IRS1) axis, this provides a new insight of the pathology of acute myocardial infarction (AMI) and a potential target for the treatment of AMI (31).