HMGB1 and Myocardial fibrosis: Other miRNAs also have important protective effects on MI, such as anti-inflammatory, anti-apoptosis, anti-oxidant stress, etc. High-mobility basal box 1 (HMGB1) can promote inflammation (63, 64), BMSC-Exos overexpression of miR-129-5p improves myocardial fibrosis, down-regulates HMGB1 expression in MI mice, reduces expression of inflammatory factors, and inhibits apoptosis (65).