Exosomes of miR-125b-5p secreted after hypoxia preconditioning target the downregulation of the apoptotic genes p53 and BRI1-associatedreceptorkinase 1 (BAK1), significantly promoting ischemic heart repair and reducing infarction size in a mouse model of myocardial infarction (61). The gene discussed is BAK1; the disease is myocardial infarction.