The overexpressed BMSC-derived exosomal miR-338 can prevent cardiomyocyte apoptosis by regulating the mitogen-activated protein kinase kinase kinase 2(MAP3K2)/c-Jun N-terminal kinase (JNK) signaling pathway and significantly repair cardiac function in a rat model of myocardial infarction (77). This evidence concerns the gene MAP3K2 and myocardial infarction.