Based on multivariable models adjusted for age, sex, education, BMI, physical activity, smoking, diabetes, hypertension, stroke, ApoE genotype, and total energy intake, high cumulative total fruit intake in the midlife group was significantly associated with decreased risk of all-cause dementia as compared to low cumulative total fruit intake (HR = 0.56; 95% CI = 0.32 – 0.98; p = 0.04) (Table 3). This evidence concerns the gene APOE and hypertensive disorder.