Heat shock transcription factor 1 (HSF1) is widely recognized as pivotal for cellular responses to diverse stresses, preserving cell function and viability through the induction of genes associated with protein quality control [13, 14], which also solidifies its role as a significant facilitator of various cancers and a critical determinant of therapeutic efficacy, including pancreatic cancer [15, 16]. Here, HSF1 is linked to pancreatic neoplasm.