In addition, sh-MFF significantly increased the content of ROS in glioma cells, but had no effect on the remodeling of MMP and MRC (Fig. 9m-o, Supplementary Fig. 12k and l); while OE-MFF significantly decreased MMP and ROS, and the abundance of MRC was also reduced (Fig. 9p-r, Supplementary Fig. 12m and n). The gene discussed is CD200; the disease is central nervous system cancer.