To further examine the status of MRC, according to the classification method proposed by Mingqi Han et al., based on the orderliness of MRC observed under the transmission electron microscope [4], glioma mitochondria were categorized into three types in our study: Type 1 exhibited dense and abundant MRC with mostly intact OMM; Type 2 showed sparse MRC (accompanied by occasional incomplete phenomenon in the OMM); and Type 3 displayed severely damaged MRC (often accompanied by incomplete phenomenon in the OMM) (Fig. 1g). Here, CD200 is linked to glioma.