FOXO3 and hepatocellular carcinoma: As a powerful compound for antitumor activities, Berberine induces G1 phase cell cycle arrest in HCC cell lines, including Huh-7 and HepG2, through inhibition of the AKT pathway leading to decreased levels of S-phase kinase-associated protein 2 (Skp2) and increased nuclear translocation of FoxO3a [61].