ACRG also proposed four molecular subtypes of GC: MSI, microsatellite stable and epithelial-to-mesenchymal transition (MSS/EMT), MSS/TP53−, and MSS/TP53+, based on whole genome sequencing (WGS) of 49 GC tumors and gene expression and copy number profiling as well as targeted gene sequencing of 251 GC tumors from Korean patients [6]. The gene discussed is TP53; the disease is gastric cancer.