ATF4 and non-small cell lung carcinoma: Herein, we found that DT-061 treatment in NSCLC cells significantly upregulated genes associated with endoplasmic reticulum (ER) stress, UPR, and integrated stress response (ISR), including HERPUD1, ATF3, DDIT3 (CHOP), TRIB3, PPP1R15A (GADD34), IRE1α, ATF6, EIF2, PERK, and ATF4 activated genes (Supplementary Fig. 1D–F).