Herein, we found that DT-061 treatment in NSCLC cells significantly upregulated genes associated with endoplasmic reticulum (ER) stress, UPR, and integrated stress response (ISR), including HERPUD1, ATF3, DDIT3 (CHOP), TRIB3, PPP1R15A (GADD34), IRE1α, ATF6, EIF2, PERK, and ATF4 activated genes (Supplementary Fig. 1D–F). Here, ERN1 is linked to non-small cell lung carcinoma.