Consistent with the findings in pNSCLC-1 cells, the knockdown of ORC6 using shORC6-2# exhibited similar effects across these primary and immortalized NSCLC cells, suppressing cell proliferation (as evidenced by reduced EdU-positive cell percentage, Fig. 4K) and inhibiting cell migration (Fig. 4L). The gene discussed is ORC6; the disease is non-small cell lung carcinoma.