In a peritoneal tumor model, the tumor induces a high level of itaconate in macrophages to up-regulate oxidative phosphorylation (OXPHOS) and mitochondrial reactive oxygen species (ROS), thereby activating mitogen-activated protein kinase (MAPK) signaling in tumor cells to promote tumor growth (Weiss et al, 2018). The gene discussed is WNK2; the disease is neoplasm.