TERF1 and renal fibrosis: These findings support the hypothesis that TRF1 depletion over an eight-week period promotes a profibrotic environment and that a low dose of the nephrotoxic agent FA is sufficient to induce full-blown renal fibrosis within the same short-term period, similar to observations made with sustained TRF1 depletion in fibroblasts throughout the mouse lifespan (Fig. 6).