TERF1 and renal fibrosis: Interestingly, long-term TRF1 depletion causes fibroblasts to acquire an exorbitant mesenchymal phenotype via the MMT, EMT and EndMT, causing extracellular matrix deposition and leading to renal fibrosis, with an increased urine albumin‒creatinine ratio (uACR) and a decline in survival rates.