Notably, the TRs of several genes, including SYNGR1, GTF2IRD2, and FAM120C, exhibited increased levels in the tumor samples of triple-negative breast cancer patients, whereas genes such as TVP23C, ICAM3, and RIMKLB displayed decreased TRs in triple-negative breast cancer tumor samples (Fig. 4a and Supplementary Fig. 4a). The gene discussed is GTF2IRD2; the disease is triple-negative breast carcinoma.