However, specific genes within the BRCA dataset such as H2AZ2 (H2A histone family member V) and LRRFIP1 (leucine-rich repeat flightless-interacting protein 1) exhibited a significant increase in TR in most tumor samples compared to normal tissues (Fig. 2c and Supplementary Fig. 2c). The gene discussed is LRRFIP1; the disease is neoplasm.