Ultimately, to pinpoint the attenuation of mTOR signalling as the mechanistic mediator of the protective effects of LPD during infection we restored mTOR signalling in LPD fed mice in vivo by dietary supplementation of leucine; an essential amino acid that directly activates the mTORC1 subunit of the mTOR complex50. Here, MTOR is linked to disseminated peritoneal leiomyomatosis.