However, while wt infection of A-498 led to ∼35% reduction in phospho-ERK1/2 (Appendix Fig. S1A), phospho-JNK1/2 levels were similar in wt-infected and uninfected A-498 (Appendix Fig. S1B), indicating that ERK signalling is downregulated upon Cg infection. The gene discussed is MAPK3; the disease is infection.