Next, to determine the in vivo relevance of the observed differential cytokine release upon infection of A-498 with wt and Cgyps1-11Δ, we checked the levels of IL-6 and KC and MIP-2 (murine homologs of IL-8) cytokines in kidney homogenates of uninfected, and wt and Cgyps1-11Δ-infected mice, with kidneys being the major target organ in the mouse systemic candidiasis model (Kaur et al, 2007; Rasheed et al, 2018). This evidence concerns the gene CXCL8 and infection.