Thrombophilia gene mutation screening was performed on the thrombotic cases with a positive family history of thromboembolic events in this study and demonstrated that Factor V Leiden mutation G1691A is the most common genetic thrombophilia mutations [18] while Dugalic et al., 2021 conducted a review of gene mutations in different regions all over the world and reported that Factor V Leiden mutation and prothrombin gene mutations are very rare in the African population positive mutation has no impact on the diagnostic and treatment strategies of neonatal thrombosis [21, 35, 36]. The gene discussed is F5; the disease is thrombophilia.