TMPRSS2 and prostate neoplasm: Several AR-associated genes (AR, FOLH1, KLK3, NKX3-1, TMPRSS2) showed minimal change in the metastatic dura adenocarcinoma as compared to the primary prostate tumor, while there was a marked downregulation of these AR-related transcripts in the metastatic brain NEPC lesion (Fig. 2e).