High levels of IFN-γ can lead to an upregulation of HLA-E on tumor cells, which has also been observed following CAR33-NK cell therapy in AML-bearing mice as well as in CAR33-KLRC1ko-NK cells following AML cell contact in vitro (Fig. 6g, i)19,46. The gene discussed is HLA-E; the disease is acute myeloid leukemia.