PVT1 and diabetic kidney disease: After induce of DKD mouse model using STZ (Fig. S2D), we found that the blood glucose levels were significantly higher in the STZ-treated groups than in the control mice at every observation point, while there were no significant differences in blood glucose levels between the STZ-Cre+/Pvt1+/+ and STZ-Cre+/Pvt1flox/flox groups (Fig. S2E), and there were no significant differences in SBP among the four groups before 20 weeks (Fig. S2F).