PVT1 and diabetic kidney disease: Moreover, at 20 weeks after DKD initiation, the kidney weight to body weight ratio in the STZ-Cre+/Pvt1+/+ mice was higher than that in the control group, whille the ratio in the STZ-Cre+/Pvt1flox/flox mice was decreased compared with that in the STZ-Cre+/Pvt1+/+ group (Fig. 2B), suggesting kidney hypertrophy is prevented in the Pvt1 knockout mice.