The results of OCR revealed that the mitochondrial respiration of hyperglycemia-treated podocytes was decreased at both basal and maximal levels, and accompanied by decreased spare respiratory capacity and ATP production, thereby switching to quiescent metabolism, while the transfection of PVT1 ASO ameliorated mitochondrial damage status (Figs. 3B, C, S3B). Here, PVT1 is linked to Hyperglycemia.