PVT1 and diabetic kidney disease: STZ-treated mice exhibited a significantly higher ACR levels compared with the control mice at 8 weeks, 12 weeks, 16 weeks and 20 weeks after DKD initiation, while the STZ-Cre+/Pvt1flox/flox mice exhibited lower albuminuria levels than those of the STZ-Cre+/Pvt1+/+ mice after 8 weeks of DKD (Fig. 2C).