Indeed, the ubiquitination of AMPKα was markedly enhanced in the context of hyperglycemia when compared to LG group in podocytes, knockdown of TRIM56 in podocytes attenuated HG-induced AMPKα ubiquitination, while the overexpression of TRIM56 promoted the ubiquitination of AMPKα (Fig. 5F), suggesting that ubiquitin-dependent degradation of AMPKα may be associated with E3 ubiquitin ligase TRIM56. Here, TRIM56 is linked to Hyperglycemia.