Indeed, as shown in Fig. 4A, we found that the ABCA1-overexpressed lung cancer cells (A549 and H1650 cells) with extremely low cholesterol levels (which shown in Fig. 3D) were significantly more sensitive to gilteritinib than the control cells with high cholesterol (which shown in Fig. 2G, H), indicating that the gilteritinib-induced cholesterol accumulation attenuates its antitumor activity and ABCA1-mediated low-cholesterol levels sensitizes lung cancer cells to gilteritinib. Here, ABCA1 is linked to lung carcinoma.