Beyond facilitating oncogenic cascades triggered by activated cell surface receptors, Gαi1 and Gαi3 are overexpressed in various human malignancies, including glioma, osteosarcoma, cervical cancer, and nasopharyngeal carcinoma, where they correlate with poor prognosis [16, 24, 25, 28, 48]. Here, CD177 is linked to osteosarcoma.