Hence, the suppression of PKA activity by Gαi3 inactivated the LATS1/2 kinase cascade within the Hippo pathway, thereby leading to YAP dephosphorylation and promoting its nuclear translocation in pancreatic cancer cells, indicating that Gαi3 mitigates PKA-induced inhibition of YAP/TAZ activity in pancreatic cancer cells. The gene discussed is YAP1; the disease is pancreatic neoplasm.