Additionally, an increase in PD-L1-positive cells was detected in pancreatic cancer tissues with higher Gαi3 expression, suggesting a mechanism for pancreatic cancer cell immune evasion by upregulating the surface expression of PD-L1, thereby inhibiting T cell function through interaction with PD-1 receptor on T cells [61–63]. The gene discussed is CD274; the disease is familial pancreatic carcinoma.