The heterogeneity of pancreatic cancer is marked by extensive genomic, proteomic, and epigenetic alterations affecting various core signaling pathways, such as RTKs, TGF-β receptor, Akt-mTOR, SWI/SNF complex, Wnt/Notch, JNK, and Hippo signaling [45–47]. Here, MAPK8 is linked to pancreatic neoplasm.