Additionally, analysis of pancreatic cancer tissues from four patients (Patient-1#/-2#/-3#/-4#) revealed a significantly higher binding of TCF7L2 to the proposed Gαi3 promoter compared to adjacent normal pancreatic tissues (Fig. 8H), suggesting that enhanced TCF7L2-Gαi3 promoter interaction might be a fundamental mechanism contributing to Gαi3 overexpression in pancreatic cancer. Here, TCF7L2 is linked to familial pancreatic carcinoma.