FASN and cancer: In addition, FASN expression was positively correlated with a signature corresponding to the top 100 CRISPR-mediated gene dependencies similar to FASN identified in the Cancer Cell Line Encyclopedia (breast cancer TCGA PCC = 0.30, p = 4 × 10−24; pan-cancer TCGA PCC = 0.75, p < 10−16; Fig. S3) [25].