FASN and cancer: FASN expression measured by RNA sequencing (RNA-seq) in The Cancer Genome Atlas (TCGA) [23] was considered to be biologically relevant as it was found to positively correlate with curated gene signatures of lipid metabolism and AMPK signaling [24] in both the breast cancer and pan-cancer datasets (Pearson correlation coefficient [PCC] = 0.28–0.30, p-values < 10−21; Fig. S2).