Accordingly, we demonstrated that CATs and BCL-2/BCL-XL-targeting BH3 mimetics markedly synergized in killing FASN KO cancer cells, strongly supporting the notion that suppression of FASN metabolic signaling may make cancer cells easier targets for pro-apoptotic, cytotoxic signals from CATs by altering the BCL2 interactome. Here, PIMREG is linked to cancer.