CD274 and neoplasm: However, since palmitate depletion via FASN inhibition significantly alters cell membrane composition and function in tumor cells, it cannot be excluded that FASN suppression could promote dissociation of PD-L1 from the cell membrane to make its C272 palmitoylation site less accessible to DHHCs and substrate [112], thereby indirectly decreasing PD-L1 palmitoylation and increasing PD-L1 degradation.