To mimic the physiological and pathological states of human PTC, we established PTC tumor-bearing mouse models using PTC cell lines with NC (normal control), sh-AdipoR1 (AdipoR1 gene silencing), sh-AdipoR2 (AdipoR2 gene silencing), and sh-ULK1 (ULK1 gene silencing). This evidence concerns the gene ULK1 and neoplasm.