NPM1 mutations are disease-defining genetic lesions serving as gatekeepers for AML,1,7,8 whereas FLT3 mutations are considered late events.9,10 Although NPM1 mutations are most commonly found in AML, they have also been described in other myeloid neoplasms (MNs), including CMML and myelodysplastic syndrome (MDS). The gene discussed is NPM1; the disease is acute myeloid leukemia.