NPM1 and acute myeloid leukemia: There is currently no clear consensus on whether chronic myelomonocytic leukemia (CMML) with NPM1 mutations (NPM1mut) should be diagnosed and treated as acute myeloid leukemia (AML).1,2 Here we report the case of a patient who was diagnosed based on morphological, clinical, and molecular data and treated in a risk-adapted manner.