GRN and clostridium difficile infection: Histological evaluation of the colon by H&E staining showed that PGRN loss resulted in a significant increase in epithelial damage and sub-mucosal edema (Figure 2b), and the number of goblet cells per upper crypt in the colonic mucosa was significantly decreased in PGRN KO mice when compared with WT mice during CDI (Figure 2c).