IL22 and clostridium difficile infection: αβ T cells, natural killer (NK) cells, γδ T cells, and innate lymphoid cells (ILCs) are producers of IL-22.37 To determine the phenotype of IL-22-producing cells regulated by PGRN during CDI, intestinal cells in the colon tissues were isolated after CDI, stained for cell markers and cytoplasmic IL-22, and analyzed by flow cytometry.