Due to this trend, and because of the role of BMP signaling and neurogenesis in response to stress (Gould et al., 1997; Malberg and Duman, 2003; Pham et al., 2003; Mirescu and Gould, 2006; Czéh et al., 2007; Mori et al., 2020), we placed mice under acute and chronic restraint stress to assess the ability of Grem2−/− mice to mitigate their anxiety under stressful scenarios (Fig. 4A,B). The gene discussed is GREM2; the disease is Anxiety.