Of note, however, in contrast to the effect of Ift88 siRNA, which increased baseline mechanical nociceptive threshold, inhibitors of Hh signaling, in the absence of inflammation or peripheral neuropathy, did not affect nociceptive threshold, supporting the presence of an Hh-independent primary cilium function capable of regulating baseline mechanical nociceptive threshold. This evidence concerns the gene IFT88 and peripheral neuropathy.