Reflecting the quantity and ability of CD8 T-cells to infiltrate the tumour parenchyma, we grouped HCC specimen with a CD8 T-cell density below 200 per mm2 as immune-depleted (58.5%) while HCCs with a CD8 T-cell density above this cut-off were further classified into compartmentalised (18.9%) or immune-enriched (22.6%) based on the ratio between parenchymal and stromal CD8 T cell densities below or above 0.5, respectively, as illustrated in figure 3D. This evidence concerns the gene CD8A and hepatocellular carcinoma.