CD8A and neoplasm: Interestingly, while the stromal CD8 T-cell density did not differ between enriched and compartmentalised HCCs, the difference in quantity was due to significant infiltration of CD8 T-cells into the tumour parenchyma in these groups that both harboured high levels of immune cells, a feature only revealed by integrating the spatial microenvironment component of the analysis (figure 3E).