Zhang et al's study on hamsters was the solein vivoinvestigation performed.18The study revealed that, by increasing Bax expression, decreasing BCl-2 expression, and preventing transactivation of the NF-κB gene involved in oncogenesis, quercetin reduces tumor incidence and promotes apoptosis.19Zhang et al also conducted research on BALB/c nude mice, stating that quercetin inhibited OSCC tumor growth partly through regulating the miR-22/WNT1/β-catenin axisin vivo. This evidence concerns the gene WNT1 and neoplasm.