Because the difference in virological phenotypes between SA11 and SA11 expressing RRV NSP1s did not appear until 10 days post infection (Fig 3B and 3C), a few days later than the pathological manifestation (Fig 1), we next examined the effects of RRV NSP1 on extraintestinal pathological changes in the liver, biliary system, and pancreas following enteric infection with parental rRRV, rSA11, or the NSP1 monoreassortant viruses on 10 days post infection. Here, SH2D3A is linked to infection.