Then the PPI network of scDEGs identified top-ranked eight scDEGs (PLG, ENO2, ALDOB, UMOD, ALDH6A1, SLC12A3, SLC12A1, SERPINA5) as the ccRCC-causing KGs (Fig 2). The pan-cancer analysis also significantly supported their association with ccRCC. This evidence concerns the gene SERPINA5 and cancer.