Furthermore, miR-374a-targeted genes exhibited significant association with pathways such as cancer, Ras signaling, MAPK signaling, PI3K-AKT signaling, Glioblastoma signaling, EGFR tyrosine kinase inhibitor resistance, mTOR signaling, miRs in cardiomyocyte hypertrophy, EGF/EGFR signaling and glioma (Fig 7C). This evidence concerns the gene EGF and central nervous system cancer.