Similarly, miR-126-targeted genes displayed significant involvement in 82 KEGG pathways, 89 Wiki Pathways, and relevant processes such as MAPK signaling, cancer pathways, Ras signaling, PI3K/AKT signaling, EGF/EGFR signaling, mTOR signaling, Glioma, miRs in cancer, miRs in cardiomyocyte hypertrophy, Autophagy, and Pilocytic astrocytoma (Fig 7B). This evidence concerns the gene EGF and central nervous system cancer.