Furthermore, our study revealed a significant downregulation of ULK2 expression in high-grade gliomas compared to low-grade ones, consistent with findings by Shulka et al. This downregulation of ULK2 in glioblastoma aligns with reported promoter hypermethylation and ULK2 downregulation in normal brain tissue. Here, ULK2 is linked to glioblastoma.