Three patterns of changes were found comparing the twelve metabolism-regulatory mRNAs between healthy control, NTCT and tumor: (1) Upregulated in NTCT and tumor; (2) Upregulated only in NTCT (MED12); (3) Upregulated in NTCT but downregulated in tumor (ZNF395) (Fig. 2). Here, ZNF395 is linked to neoplasm.