SRCAP and cancer: Being implicated in many disorders, for example, a recent study indicated that a competitive advantage in SRCAP mutant HSCs enriched in patients following genotoxic stress led to the development of clonal hematopoiesis with a lymphoid-biased expansion (Chen et al. 2023), the precise modulation by chromatin remodelers is a critical determinant in the fate control of TSCs, which can tell us that the dysfunction of chromatin remodelers could lead to the disruption of tissue homeostasis, predisposing individuals to disorders, developmental diseases and cancer.