In addition, the S1P signaling axis was observed to be relevant in neuropathy and chemotherapy-induced neuropathic pain, which led to the suggestion of targeting S1P receptors as a novel approach to ameliorate chemotherapy-induced neuropathy and neuropathic pain (Janes et al., 2014; Wang et al., 2020; Salvemini et al., 2013; Becker et al., 2020; Chua et al., 2020). This evidence concerns the gene MBTPS1 and neuropathy.