In agreement, Aimaier et al demonstrated a direct role for FOXM1 in promoting MPNST pathogenesis through knockdown and overexpression studies [26] while we have discovered that FOXM1 expression and transcriptional activity are greatly increased as benign human precursor pNFs transform into MPNSTs (unpublished data). The gene discussed is FOXM1; the disease is malignant peripheral nerve sheath tumor.