We further inserted the MDA5-exon1 into pmirGLO, and results showed that the infection of SCRV can reduce the luciferase activity of pmirGLO-MDA5-exon1, and the use of cycloleucine (CL, an amino acid analogue that can inhibit m6A modification) hindered the degradation of MDA5-exon1 by SCRV, indicating that SCRV can regulate MDA5 expression through a methylation mechanism (Figure 5G). Here, IFIH1 is linked to infection.