TMPRSS2 and neoplasm: Figure 2 depicts the Kaplan–Meier plots of progression-free survival of the seven states. We observed a clear trend of worsening survival functions along paths A, B, and C. Specifically, the clinical outcomes of the tumor samples in states 3, 4, and 6 were significantly worse than those in states 1, 2, and 5 [HR = 2.11 (1.40–3.19); P = 0.001]. It was noted that the survival outcomes cannot be predicted by the TMPRSS2–ERG fusion status, which is consistent with previous findings (35).