PILRA and neoplasm: Again, the overall trend of gene expression was downregulation along path C, whereas module 1 expression was increased and module 2 expression was stable in path D. Module 1 includes MSR1, THY1, and PILRA, reported to be potential tumor suppressors (102–104), perhaps explaining, in part, why path D/state 7 represents a branch with a relatively good prognosis (Fig. 2).